The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Feb. 14, 2006

Filed:

Nov. 26, 2003
Applicants:

Raymond E. Conrow, Crowley, TX (US);

Pete Delgado, Fort Worth, TX (US);

William D. Dean, Arlington, TX (US);

David R. Pierce, Fort Worth, TX (US);

Michael S. Gaines, Fort Worth, TX (US);

Inventors:

Raymond E. Conrow, Crowley, TX (US);

Pete Delgado, Fort Worth, TX (US);

William D. Dean, Arlington, TX (US);

David R. Pierce, Fort Worth, TX (US);

Michael S. Gaines, Fort Worth, TX (US);

Assignee:

Alcon, Inc., Hünenberg, CH;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 231/56 (2006.01);
U.S. Cl.
CPC ...
Abstract

Methods of making indazoles are described. The methods involved reacting an aromatic aldehyde with a nitrogen source to form a nitroso aromatic aldehyde. The nitroso aromatic aldehyde is reacted with a reducing agent to form an indazole which ultimately can be used to form desired indazoles which are preferably pharmaceutically active products. The process of the present invention further permits the formation of enantiomerically enriched or pure indazoles such as aminoalkyl indazoles.


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