The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 14, 2006
Filed:
Aug. 15, 2003
Kazuki Yano, Tochigi, JP;
Fumie Kobayashi, Tochigi, JP;
Masaaki Goto, Tochigi, JP;
Naohiro Washida, Tochigi, JP;
Eisuke Tsuda, Tochigi, JP;
Kaoji Higashio, Saitama, JP;
Yoshiji Yamada, Aichi, JP;
Kazuki Yano, Tochigi, JP;
Fumie Kobayashi, Tochigi, JP;
Masaaki Goto, Tochigi, JP;
Naohiro Washida, Tochigi, JP;
Eisuke Tsuda, Tochigi, JP;
Kaoji Higashio, Saitama, JP;
Yoshiji Yamada, Aichi, JP;
Sankyo Co., Ltd., Tokyo, JP;
Abstract
A method of diagnosing metabolic bone diseases, especially osteoporosis and arthrosis characterized by determining the concentration of osteoclastgenesis inhibitory factor (OCIF) in humor. Monoclonal antibodies recognizing equally both of monomer type and dimer type of OCIF. Monoclonal antibodies recognizing selectively dimer type of OCIF. And to provide an assay kit for determination of OCIF concentration comprising the aforementioned two antibodies recognizing different epitope of OCIF and having high affinity showing dissociation constant of less than 2×10M with antigen. It is useful for a method of diagnosing metabolic bone diseases, especially osteoporosis and arthrosis or for an assay reagent for research thereof.