The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 07, 2006
Filed:
Jan. 08, 2004
Applicants:
Hisayuki Tsujimori, Kurume, JP;
Tatsuya Yamaguchi, Kurume, JP;
Inventors:
Hisayuki Tsujimori, Kurume, JP;
Tatsuya Yamaguchi, Kurume, JP;
Assignee:
Otsuka Pharmaceutical Co., Ltd., Tokyo, JP;
Primary Examiner:
Int. Cl.
CPC ...
C07D 401/12 (2006.01);
U.S. Cl.
CPC ...
Abstract
The present invention provides a process for preparing aripiprazole in a high purity and a high yield. According to the process of the present invention, aripiprazole is prepared by the reaction of a carbostyril compound represented by general formula (2):(wherein X is halogen atom, lower alkanesulfonyloxy group, arylsulfonyloxy group or an aralkylsulfonyloxy group), with a piperazine compound represented by formula (3):and/or a salt thereof in water, in the presence of 0.5 to 10 mol of an inorganic basic compound, per mol of the carbostyril compound (2).