The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 07, 2006
Filed:
Jan. 13, 2005
Ralph A. Zingaro, College Station, TX (US);
Emil J. Freireich, Houston, TX (US);
Hatice Duzkale, Houston, TX (US);
Hagop Kantarjian, Bellaire, TX (US);
Srdan Verstovsek, Houston, TX (US);
Merida Sotelo-lerma, Hermosillo, MX;
Ralph A. Zingaro, College Station, TX (US);
Emil J. Freireich, Houston, TX (US);
Hatice Duzkale, Houston, TX (US);
Hagop Kantarjian, Bellaire, TX (US);
Srdan Verstovsek, Houston, TX (US);
Merida Sotelo-Lerma, Hermosillo, MX;
Board of Regents, The University of Texas System, Austin, TX (US);
The Texas A&M University System, College Station, TX (US);
Abstract
Arsenic trioxide, an inorganic compound, is commercially available anti-cancer agent but it carries significant toxicity. Organic arsenicals, on the other hand, are much less toxic, to the extent that the methylation of inorganic arsenic in vivo into organic arsenicals has been considered a detoxification reaction. New organic arsenic derivatives have been synthesized, including S-dimethylarsino-glutathione, S-dimethylarsino-thiosuccinic acid and S-dimethylarsino-thiobenzoic acid, and established its potent in vitro cytotoxic activity against numerous human tumor cell lines, both of solid and hematological origin, as well as against malignant blood cells from patients with leukemia. Results form a basis for the development of S-dimethylarsino-glutathione, S-dimethylarsino-thiosuccinic acid, S-dimethylarsino-thiobenzoic acid, and other organic arsenicals as an anti-cancer therapy, combining high efficacy with very low, if any, toxicity.