The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 07, 2006
Filed:
Jan. 08, 2002
Vincent P. Stanton, Jr., Belmont, MA (US);
Jia Liu Wolfe, Winchester, MA (US);
Tomohiko Kawate, Cambridge, MA (US);
Charles Allerson, Cambridge, MA (US);
Gregory L. Verdine, Cambridge, MA (US);
Vincent P. Stanton, Jr., Belmont, MA (US);
Jia Liu Wolfe, Winchester, MA (US);
Tomohiko Kawate, Cambridge, MA (US);
Charles Allerson, Cambridge, MA (US);
Gregory L. Verdine, Cambridge, MA (US);
Sequenom, Inc., San Diego, CA (US);
Abstract
The present invention relates to methods for the detection of polymorphisms by substituting a base-modified nucleotide for a natural nucleotide in a polynucleotide. The base-modified nucleotide renders the polynucleotide more susceptible to cleavage at the sites of its incorporation than site consisting of natural nucleotides. The fragments obtained are then analyzed to determine the presence or absence of a polymorphism.