The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 31, 2006
Filed:
Jun. 07, 1995
Dean Engelhardt, New York, NY (US);
Elazar Rabbani, New York, NY (US);
Stanley Kline, Brooklyn, NY (US);
Janes G. Stavrianopoulos, New York, NY (US);
Dollie Kirtikar, Elmhurst, NY (US);
Dean Engelhardt, New York, NY (US);
Elazar Rabbani, New York, NY (US);
Stanley Kline, Brooklyn, NY (US);
Janes G. Stavrianopoulos, New York, NY (US);
Dollie Kirtikar, Elmhurst, NY (US);
Enzo Life Sciences, Inc. c/o Enzo Biochem, Inc., Farmingdale, NY (US);
Abstract
The present invention provides a nucleotide having the formula,Sig-PM-SM-BASEwherein PM is a phosphate moiety, SM is a sugar moiety and BASE is a pyrimidine, purine or 7-deazapurine moiety. PM is attached to the 3' or the 5′ position of the sugar moiety when the nucleotide is a deoxyribonucleotide and at the 2′, 3′ or 5′ position when the nucleotide is a ribonucleotide. BASE is attached to the 1′ position of SM from the Nposition when BASE is a pyrmidine or the Nposition when BASE is a purine or 7-deazapurine. Sig is covalently attached to PM directly or via a chemical linkage, and represents a detectable moiety covalently attached to SM directly or through a linkage group. Also provided are an oligo- or polynucleotide comprising at least one such phosphate-moiety labeled nucleotide, and other compositions including those wherein a polypeptide is terminally ligated or attached to the oligo- or polynucleotide. The phosphate-moiety labeled nucleotide, and the oligo- or polynucleotides and other compositions comprising such phosphate-moiety labeled nucleotides, are useful as diagnostic tools for detecting analytes and as therapeutic agents.