The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 31, 2006
Filed:
Oct. 15, 2001
J. Kevin Donahue, Towson, MD (US);
Eduardo Marban, Lutherville, MD (US);
Koichi Nagata, Saitama, JP;
John H. Lawrence, Pennington, NJ (US);
J. Kevin Donahue, Towson, MD (US);
Eduardo Marban, Lutherville, MD (US);
Koichi Nagata, Saitama, JP;
John H. Lawrence, Pennington, NJ (US);
The Johns Hopkins University, Baltimore, MD (US);
Abstract
The present provides methods and compositions that enable effective delivery of nucleic acids to desired cells, including to a solid organ such as a mammalian heart. The methods and compositions enable effective gene transfer and subsequent expression to a majority of cells throughout a solid organ such as the heart. Methods and compositions of the invention preferably provide enhanced vascular permeability that enables increased gene transfer to targeted cells, but without significant degradation or injury to endothelial cell layers.