The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 31, 2006
Filed:
Nov. 20, 2001
Joseph S. Adorante, Irvine, CA (US);
George R. Ehring, Huntington Beach, CA (US);
John Donello, Dana Point, CA (US);
Joseph S. Adorante, Irvine, CA (US);
George R. Ehring, Huntington Beach, CA (US);
John Donello, Dana Point, CA (US);
Allergan, Inc., Irvine, CA (US);
Abstract
A method for identifying a Nachannel blocker, including providing a cell containing a Nachannel, demonstrating both a transient and a persistent current. The cell includes a potassium (K) channel and a Na/K ATPase (Napump). A fluorescent dye is disposed into the well. The fluorescent dye is sensitive to change in cell membrane potential in order to enable optical measurement of cell membrane potential. A Nachannel blocker, to be identified, is added to the well and a stimulating current is passed through the cell in an amount sufficient to generate an action potential before and after the addition of the Nachannel blocker. Thereafter, a change in cell membrane potential is optically measured.