The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 24, 2006
Filed:
May. 31, 2002
Howard P. NG, El Sobrante, CA (US);
Zhihong LI, Burlingame, CA (US);
Danny P. C. Mcgee, Vista, CA (US);
Oliver L. Saunders, Burlingame, CA (US);
Guoxian Wu, Foster City, CA (US);
David J. King, Belmont, CA (US);
Valeri Martichonok, San Francisco, CA (US);
Sharon Boyd, San Bruno, CA (US);
Thomas J. Lobl, Foster City, CA (US);
Howard P. Ng, El Sobrante, CA (US);
Zhihong Li, Burlingame, CA (US);
Danny P. C. McGee, Vista, CA (US);
Oliver L. Saunders, Burlingame, CA (US);
Guoxian Wu, Foster City, CA (US);
David J. King, Belmont, CA (US);
Valeri Martichonok, San Francisco, CA (US);
Sharon Boyd, San Bruno, CA (US);
Thomas J. Lobl, Foster City, CA (US);
Medarex, Inc., Princeton, NJ (US);
Abstract
The present invention provides analogues of duocarmycins that are potent cytotoxins. Also provided are peptidyl and disulfide linkers that are cleaved in vivo. The linkers are of use in forming prodrugs and conjugates of the cytotoxins of the invention as well as other diagnostic and therapeutic moieties. The invention provides prodrugs and conjugates of the duocarmycin analogues with the linker arms of the invention.