The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 24, 2006
Filed:
Apr. 14, 2003
Andre Rosowsky, Needham, MA (US);
Henry Bader, Canton, MA (US);
Peter Blumbergs, Royal Oak, MI (US);
Ming-the Lin, Farmington Hills, MI (US);
Andre Rosowsky, Needham, MA (US);
Henry Bader, Canton, MA (US);
Peter Blumbergs, Royal Oak, MI (US);
Ming-The Lin, Farmington Hills, MI (US);
Dana-Farber Cancer Institute, Boston, MA (US);
Ash Stevens, Inc., Detroit, MI (US);
Abstract
In one embodiment, the present invention relates to a new class of ammonium salts of N-acyl derivatives of N-(4-amino-4-deoxypteroyl)-L-ornithine compounds having a structure according to formula II-IV. Formula II has the structure of: The ammonium salts provided by the invention exhibit high inhibitory activity against the growth o methotrexate-resistant cells, and also exhibit superior chemical stability than corresponding acidic N-acyl derivatives of N-acyl derivatives of N(4-amino-4-deoxypteroyl)-L-ornithine compounds.