The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 24, 2006
Filed:
Oct. 08, 1998
Elliott Richelson, Ponte Vedra Beach, FL (US);
Beth Marie Tyler, Neptune Beach, FL (US);
Bernadette Marie Cusack, Jacksonville Beach, FL (US);
Christopher Lee Douglas, Jacksonville, FL (US);
Karen Jansen, Jacksonville, FL (US);
Elliott Richelson, Ponte Vedra Beach, FL (US);
Beth Marie Tyler, Neptune Beach, FL (US);
Bernadette Marie Cusack, Jacksonville Beach, FL (US);
Christopher Lee Douglas, Jacksonville, FL (US);
Karen Jansen, Jacksonville, FL (US);
Mayo Foundation for Medical Education and Research, Rochester, MN (US);
Abstract
The invention involves methods and materials for extracellularly administering PNA oligomers to living cells. Specifically, the invention provides methods and materials of treating living cells with PNA oligomers such that the oligomers cross biological barriers and engender a biological response in a sequence specific manner. In addition, the invention provides methods and materials for orally administering PNA oligomers to animals such that the oligomers cross biological barriers and engender a biological response in a sequence specific manner. The invention also provides sense and antisense PNA oligomers that modulate transcription and translation, respectively. The invention also provides mismatch PNA oligomers that modulate the degree of an engendered biological response. In addition, the invention provides methods and materials for detecting PNA oligomers within a biological sample collected from an animal. Further, the invention provides methods and materials for screening potential PNA oligomers for the ability to engender a sequence specific biological response. Further, the invention provides methods of identifying the function of polypeptides and of determining the relative turnover rate of functional polypeptides.