The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 17, 2006
Filed:
Oct. 12, 2001
Chad A. Mirkin, Wilmette, IL (US);
Robert L. Letsinger, Wilmette, IL (US);
Robert C. Mucic, Glendale, CA (US);
James J. Storhoff, Evanston, IL (US);
Robert Elghanian, Skokie, IL (US);
Thomas A. Taton, Little Canada, MN (US);
Chad A. Mirkin, Wilmette, IL (US);
Robert L. Letsinger, Wilmette, IL (US);
Robert C. Mucic, Glendale, CA (US);
James J. Storhoff, Evanston, IL (US);
Robert Elghanian, Skokie, IL (US);
Thomas A. Taton, Little Canada, MN (US);
Nanosphere, Inc., Northbrook, IL (US);
Abstract
The invention provides methods of detecting a nucleic acid. The methods comprise contacting the nucleic acid with one or more types of particles having oligonucleotides attached thereto. In one embodiment of the method, the oligonucleotides are attached to nanoparticles and have sequences complementary to portions of the sequence of the nucleic acid. A detectable change (preferably a color change) is brought about as a result of the hybridization of the oligonucleotides on the nanoparticles to the nucleic acid. The invention also provides compositions and kits comprising particles. The invention further provides methods of synthesizing unique nanoparticle-oligonucleotide conjugates, the conjugates produced by the methods, and methods of using the conjugates. In addition, the invention provides nanomaterials and nanostructures comprising nanoparticles and methods of nanofabrication utilizing nanoparticles. Finally, the invention provides a method of separating a selected nucleic acid from other nucleic acids.