The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jan. 10, 2006

Filed:

Jan. 21, 2003
Applicants:

James Robert Henry, Indianapolis, IN (US);

Yihong LI, Carmel, IN (US);

Inventors:

James Robert Henry, Indianapolis, IN (US);

YiHong Li, Carmel, IN (US);

Assignee:

Eli Lilly and Company, Indianapolis, IN (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/36 (2006.01); A61K 31/195 (2006.01); C07D 317/44 (2006.01); C07C 323/63 (2006.01); C07C 275/28 (2006.01);
U.S. Cl.
CPC ...
Abstract

The present invention is directed to compounds of the structural formula (I), and pharmaceutically acceptable salts, solvates and hydrates thereof: Formula I (a) R1, R2 and R6 are each independently selected from the group consisting of hydrogen, C-Calkyl substituted C-Calkyl, aryl-C-alkyl, substituted aryl-C-alkyl, heteroaryl-C-alkyl, substituted heteroaryl-C-alkyl, C-Ccycloalkylaryl-C-alkyl, and substituted C-Ccycloalkylaryl-C-alkyl; (b) X is an optionally substituted C-Calkylene linker wherein one carbon atom of the linker may be replaced with O, NH or S; (c) Y is C, O, S, NH or a single bond; and (d) E is selected from the group consisting of hydrogen, C(R3)(R4)A, A, (CH)COOR19 and substituted (CH)COOR19.


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