The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 10, 2006
Filed:
Aug. 01, 2001
Michael F. Clarke, Ann Arbor, MI (US);
Sean J. Morrison, Ann Arbor, MI (US);
Max S. Wicha, Ann Arbor, MI (US);
Muhammad Al-hajj, Ann Arbor, MI (US);
Michael F. Clarke, Ann Arbor, MI (US);
Sean J. Morrison, Ann Arbor, MI (US);
Max S. Wicha, Ann Arbor, MI (US);
Muhammad Al-Hajj, Ann Arbor, MI (US);
Regents of the University of Michigan, Ann Arbor, MI (US);
Abstract
A small percentage of cells within an established solid tumor have the properties of stem cells. These solid tumor stem cells give rise both to more tumor stem cells and to the majority of cells in the tumor that have lost the capacity for extensive proliferation and the ability to give rise to new tumors. The solid tumor heterogeneity reflects the presence of tumor cell progeny arising from a solid tumor stem cell. This discovery is the basis for solid tumor stem cell compositions, methods for distinguishing functionally different populations of tumor cells, methods for using these tumor cell populations for studying the effects of therapeutic agents on tumor growth, and methods for identifying and testing novel anti-cancer therapies directed to solid tumor stem cells.