The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 03, 2006
Filed:
Dec. 22, 2003
David L. Burgoyne, Delta, CA;
Gueijun Ji, Richmond, CA;
Eugene W. Kelleher, Arlington, MA (US);
Nicholas D. Paschalides, Marlborough, MA (US);
Kishore Ramachandran, Burlington, MA (US);
Yaping Shen, Port Coquitlam, CA;
Yuanlin Zhou, Richmond, CA;
David L. Burgoyne, Delta, CA;
Gueijun Ji, Richmond, CA;
Eugene W. Kelleher, Arlington, MA (US);
Nicholas D. Paschalides, Marlborough, MA (US);
Kishore Ramachandran, Burlington, MA (US);
Yaping Shen, Port Coquitlam, CA;
Yuanlin Zhou, Richmond, CA;
Inflazyme Pharmaceuticals Ltd., Richmond, CA;
Abstract
Steroids containing a cyclohexene moiety are efficiently oxidized to the corresponding α,β-unsaturated ketone using copper iodide and t-butyl hydroperoxide. A steroid compound containing the α,β-unsaturated ketone structure is efficiently converted to the corresponding vicinal diol using a hydroborating reagent followed by oxidative workup, e.g., borane followed by sodium perborate. Benzoyl and substituted benzoyls are superior protecting groups for hydroxyl groups present in the compounds.