The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 03, 2006
Filed:
Dec. 17, 2001
Compositions, methods and kits relating to thrombin degradation resistant fibroblast growth factor-1
Thomas Maciag, Freeport, ME (US);
David S. Ettenson, Somerville, MA (US);
Wilson H. Burgess, Clifton, VA (US);
William N. Drohan, Springfield, VA (US);
Thomas Maciag, Freeport, ME (US);
David S. Ettenson, Somerville, MA (US);
Wilson H. Burgess, Clifton, VA (US);
William N. Drohan, Springfield, VA (US);
Maine Medical Center Research Institute, Searborough, ME (US);
Repair, Inc., Portland, ME (US);
Abstract
The invention relates to novel degradation resistant FGF-1, and methods for producing and using the same. More specifically, the invention relates to identification of a thrombin degradation resistant FGF-1, an a nucleic acid encoding the same. The thrombin degradation resistant FGF-1 can elicit responses that are otherwise typically impeded by degradation of FGF-1 by thrombin. Thrombin degradation resistant FGF-1 is an important molecule for effecting an FGF-1 response that would be otherwise inhibited by thrombin. Thus, the present invention provides a powerful therapeutic for diseases or disorders wherein an FGF-1 response can mediate a reduction in the frequency or intensity of a symptom of the disease or disorder but for degradation of FGF-1 before it can effect the response.