The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jan. 03, 2006

Filed:

Aug. 27, 1997
Applicants:

Stuart L. Schreiber, Boston, MA (US);

Peter J. Belshaw, Somerville, MA (US);

Gerald Crabtree, Woodside, CA (US);

Inventors:

Stuart L. Schreiber, Boston, MA (US);

Peter J. Belshaw, Somerville, MA (US);

Gerald Crabtree, Woodside, CA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 48/00 (2006.01); C12N 5/00 (2006.01); C12N 15/00 (2006.01); C12N 15/63 (2006.01); C12N 15/74 (2006.01);
U.S. Cl.
CPC ...
Abstract

This invention is directed to a modified cyclosporin A and to a modified, genetically engineered version of its receptor, cyclophilin. This invention is further directed to a method for treating host versus graft disease following blood marrow transplantation by transfecting stem cells so that after introduction into a patient the stem cells will express the modified cyclophilin, and, as necessary, administer the modified cyclosporin A to the patient.


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