The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 27, 2005
Filed:
Dec. 23, 1994
Ilka Von Hoegen, Doffenheim, DE;
Uwe Hofmann, Alsbach, DE;
Carlota-silvia Jaggle, Darmstadt, DE;
Wolfgang Strittmatter, Ober-Ramstadt, DE;
Jörg Stadlmüller, Seeheim, DE;
Siegfried Matzku, Zwingenberg, DE;
Ilka von Hoegen, Doffenheim, DE;
Uwe Hofmann, Alsbach, DE;
Carlota-Silvia Jaggle, Darmstadt, DE;
Wolfgang Strittmatter, Ober-Ramstadt, DE;
Jörg Stadlmüller, Seeheim, DE;
Siegfried Matzku, Zwingenberg, DE;
Merck Patent GmbH, Darmstadt, DE;
Abstract
The present invention relates to new fusion proteins which consist of a tumor-associated targeting element preferentially a monoclonal antibody or a fragment thereof recognizing a molecule which is preferentially expressed on human tumor cells such as the human epidermal growth factor receptor (EGFR), and a biologically active ligand such as a growth and/or differentiation factor. The resulting fusion protein may be used to deliver the biologically active ligand to a specific target cell or tissue. The new immunoconjugates can be used in tumor therapy.