The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 27, 2005
Filed:
Dec. 19, 2001
Daniel S. Sem, San Diego, CA (US);
Maurizio Pellecchia, San Diego, CA (US);
Daniel S. Sem, San Diego, CA (US);
Maurizio Pellecchia, San Diego, CA (US);
Triad Therapeutics, Inc., San Diego, CA (US);
Abstract
A method for preferentially observing an exposed position () of a macromolecule. A sample is obtained having a macromolecule () with a first proton () and a second molecule () with a second proton (); then applying a magnetic field () to the sample and irradiating the sample with a pulse sequence () that preferentially demagnetizes protons of the macromolecule () relative to the second proton (); allowing the second proton () to exchange () with an exposed proton () of the macromolecule; and detecting the magnetization from the relatively magnetized second proton (), which is now bound to the exposed position () of the macromolecule. The invention also provides a method for observing a position in the macromolecule that bind a ligand.