The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 20, 2005
Filed:
Aug. 22, 2001
Terrence R. Burke, Jr., Bethesda, MD (US);
Chang-qing Wei, Ottawa, CA;
Johannes H. Voigt, Union, NJ (US);
Yang Gao, Branford, CT (US);
Terrence R. Burke, Jr., Bethesda, MD (US);
Chang-Qing Wei, Ottawa, CA;
Johannes H. Voigt, Union, NJ (US);
Yang Gao, Branford, CT (US);
The United States of America as represented by the Department of Health & Human Services, Washington, DC (US);
Abstract
Disclosed are compounds for SH2 domain binding inhibition. For example, disclosed is a compound of formula (I)wherein Ris a lipophile; R, in combination with the phenyl ring, forms a phenylphosphate mimic group or a protected phenylphosphate mimic group; Ris hydrogen, azido, amino, carboxyalkyl, alkoxycarbonylalkyl, aminocarbonylalkyl, or alkylcarbonylamino, wherein the alkyl portion of Rmay be optionally substituted with a substituent selected from the group consisting of halo, hydroxy, carboxyl, amino, aminoalkyl, alkyl, alkoxy, and keto; Ris a linker; AA is an amino acid; and n is 1 to 6; or a salt thereof. Also disclosed are a pharmaceutical composition, a method for inhibiting an SH2 domain from binding with a phosphoprotein and a method of treating breast cancer.
Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile