The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 20, 2005
Filed:
Mar. 01, 2002
David A. Edwards, Boston, MA (US);
Giovannia Caponetti, Piacenza, IT;
Jeffrey S. Hrkach, Somerville, MA (US);
Noah Lotan, Haifa, IL;
Justin Hanes, Baltimore, MD (US);
Abdell Aziz Ben-jebria, State College, PA (US);
Robert S. Langer, Newton, MA (US);
David A. Edwards, Boston, MA (US);
Giovannia Caponetti, Piacenza, IT;
Jeffrey S. Hrkach, Somerville, MA (US);
Noah Lotan, Haifa, IL;
Justin Hanes, Baltimore, MD (US);
Abdell Aziz Ben-Jebria, State College, PA (US);
Robert S. Langer, Newton, MA (US);
Massachusetts Institute of Technology, Cambridge, MA (US);
The Penn State Research Foundation, University Park, PA (US);
Abstract
Improved aerodynamically light particles for delivery to the pulmonary system, and methods for their preparation and administration are provided. In a preferred embodiment, the aerodynamically light particles are made of a biodegradable material and have a tap density less than 0.4 g/cmand a mass mean diameter between 5 μm and 30 μm. The particles may be formed of biodegradable materials such as biodegradable polymers. For example, the particles may be formed of a functionalized polyester graft copolymer consisting of a linear α-hydroxy-acid polyester backbone having at least one amino acid group incorporated herein and at least on poly(amino acid) side chain extending from an amino acid group in the polyester backbone. In one embodiment, aerodynamically light particles having a large mean diameter, for example greater than 5 μm, can be used for enhanced delivery of a therapeutic or diagnostic agent to the alveolar region of the lung. The aerodynamically light particles optionally can incorporate a therapeutic or diagnostic agent, and may be effectively aerosolized for administration to the respiratory tract to permit systemic or local delivery of a wide variety of incorporated agents.