The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 13, 2005
Filed:
Mar. 27, 2003
J. Jeffrey Seilhamer, Milpitas, CA (US);
John Lewicki, San Jose, CA (US);
Robert M. Scarborough, Hayward, CA (US);
J. Gordon Porter, Newark, CA (US);
J. Jeffrey Seilhamer, Milpitas, CA (US);
John Lewicki, San Jose, CA (US);
Robert M. Scarborough, Hayward, CA (US);
J. Gordon Porter, Newark, CA (US);
Scios, Inc., Sunnyvale, CA (US);
Abstract
The cDNA sequence encoding porcine brain natriuretic peptide and related genes encoding canine and human peptides with natriuretic activity are disclosed. The gene is shown to make accessible the DNAs encoding analogous natriuretic peptides in other vertebrate species. The genes encoding these NPs can be used to effect modifications of the sequence to produce alternate forms of the NPs and to provide practical amounts of these proteins. The NPs of the invention can also be synthesized chemically. The invention peptides have the formula: wherein Ris selected from the group consisting of: or a 10- to 109-amino acid sequence shown as the native upstream sequence for porcine, canine or human BNP in FIG., or a composite thereof; or the amides (NHor NR'R″) thereof, and Ris Asp-Ser-Gly-, Rcannot be Asn-Val-Leu-Arg-Arg-Tyr. The peptides of the invention can be formulated into pharmaceutical compositions and used to treat conditions associated with high extracellular fluid levels, especially congestive heart failure.