The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 06, 2005
Filed:
Jan. 23, 2002
Lori Friedman, San Francisco, CA (US);
Marcia Belvin, Albany, CA (US);
Jeffrey S. Larson, Burlingame, CA (US);
Helen Francis-lang, San Francisco, CA (US);
Gregory D. Plowman, San Carlos, CA (US);
Lori Friedman, San Francisco, CA (US);
Marcia Belvin, Albany, CA (US);
Jeffrey S. Larson, Burlingame, CA (US);
Helen Francis-Lang, San Francisco, CA (US);
Gregory D. Plowman, San Carlos, CA (US);
Exelixis, Inc., South San Francisco, CA (US);
Abstract
RRP genes are identified as modulators of the p53 or p21 pathway, and thus are therapeutic targets for disorders associated with defective p53 or p21 function. Methods for identifying modulators of p53 or p21, comprising screening for agents that modulate the activity of RRP are provided. Modulating agents identified using the methods of the invention can be used to specifically inhibit growth of tumor cells that overexpress an RRP protein. mRRP1 knockout mice are also provided.