The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 06, 2005
Filed:
Nov. 07, 2003
Minmin Qin, Pleasanton, CA (US);
Gary N. Zecherle, Novato, CA (US);
Wai-pan Chan, Castro Valley, CA (US);
Paul A. Fitzpatrick, Albany, CA (US);
Stuart Sweidler, Oakland, CA (US);
John M. Henstrand, Oakland, CA (US);
Dan J. Wendt, Walnut Creek, CA (US);
Lin Chen, San Francisco, CA (US);
Christopher M. Starr, Sonoma, CA (US);
Minmin Qin, Pleasanton, CA (US);
Gary N. Zecherle, Novato, CA (US);
Wai-Pan Chan, Castro Valley, CA (US);
Paul A. Fitzpatrick, Albany, CA (US);
Stuart Sweidler, Oakland, CA (US);
John M. Henstrand, Oakland, CA (US);
Dan J. Wendt, Walnut Creek, CA (US);
Lin Chen, San Francisco, CA (US);
Christopher M. Starr, Sonoma, CA (US);
BioMarin Pharmaceuticals Inc., Novato, CA (US);
Abstract
The present invention provides a highly purified recombinant human precursor N-acetylgalactosamine-4-sulfatase and biologically active mutants, fragments and analogs thereof as well as pharmaceutical formulations comprising highly purified recombinant human precursor N-acetylgalactosamine-4-sulfatase. The invention also provides methods for treating diseases caused all or in part by deficiencies in human N-acetylgalactosamine-4-sulfatase including MPS VI and methods for producing and purifying the recombinant precursor enzyme to a highly purified form.