The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 15, 2005
Filed:
Oct. 12, 2001
Paul D. Hanke, Urbana, IL (US);
Anthony J. Sinskey, Boston, MA (US);
Laura B. Willis, Cambridge, MA (US);
Paul D. Hanke, Urbana, IL (US);
Anthony J. Sinskey, Boston, MA (US);
Laura B. Willis, Cambridge, MA (US);
Archer-Daniels-Midland Company, Decatur, IL (US);
Massachusetts Institute of Technology, Cambridge, MA (US);
Abstract
The present invention relates to a mutated pyruvate carboxylase gene from. The mutant pyruvate carboxylase gene encodes a pyruvate carboxylase enzyme which is resistant to feedback inhibition from aspartic acid. The present invention also relates to a method of replacing the wild-type pyruvate carboxylase gene inwith this feedback-resistant pyruvate carboxylase gene. The present invention further relates to methods of the production of amino acids, preferably lysine, comprising the use of this mutant pyruvate carboxylase enzyme in microorganisms.