The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 15, 2005
Filed:
Aug. 23, 2001
Philip Anthony Harris, Durham, NC (US);
Robert N Hunter, Durham, NC (US);
Robert Walton Mcnutt, Jr., Durham, NC (US);
Lee Frederick Kuyper, Durham, NC (US);
Karen Elizabeth Lackey, Durham, NC (US);
Michael Robert Peel, Durham, NC (US);
Edgar Raymond Wood, Iii, Durham, NC (US);
Philip Anthony Harris, Durham, NC (US);
Robert N Hunter, Durham, NC (US);
Robert Walton McNutt, Jr., Durham, NC (US);
Lee Frederick Kuyper, Durham, NC (US);
Karen Elizabeth Lackey, Durham, NC (US);
Michael Robert Peel, Durham, NC (US);
Edgar Raymond Wood, III, Durham, NC (US);
SmithKline Beecham Corporation, Philadelphia, PA (US);
Abstract
The present invention is related to oxindole derivatives of structure (I), compositions containing the same, and methods of use and manufacture of the same. Such compounds generally are useful pharmacologically as agents in those disease states alleviated by the alteration of mitogen activated signaling pathways in general, and in particular in the inhibition or antagonism of protein kinases, which pathologically involve aberrant cellular proliferation. Such disease states include tumor growth, restenosis, atherosclerosis, pain and thrombosis. In particular, the present invention relates to a series of substituted oxindole compounds, which exhibit Trk family protein tyrosine kinase inhibition, and which are useful in cancer therapy and chronic pain indications.