The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 15, 2005
Filed:
Feb. 19, 2001
Akihiro Ueno, Gunma, JP;
Rika Nagao, Gunma, JP;
Tomoko Watanabe, Gunma, JP;
Hideo Ohta, Tokyo, JP;
Mikio Yagi, Gunma, JP;
Akihiro Ueno, Gunma, JP;
Rika Nagao, Gunma, JP;
Tomoko Watanabe, Gunma, JP;
Hideo Ohta, Tokyo, JP;
Mikio Yagi, Gunma, JP;
Kirin Beer Kabushiki Kaisha, Tokyo, JP;
Abstract
The present invention relates to novel isoxazole and thiazole compounds having an excellent lysophosphatidic acid (LPA) receptor antagonistic activity represented by general formula [1] or salts thereof:wherein R1 and R2 represents an optionally substituted alkyl group or the like; R3 represents a hydrogen atom or the like; R4 represent a group selected from the group consisting of (I) optionally substituted phenyl, aryl, or heterocycle, (II) substituted or nonsubstituted alkyl, and (III) substituted or nonsubstituted alkenyl, alternatively, R3 and R4 may form a ring structure together with a carbon atom to which they bind; and X represents an oxygen atom or a sulfur atom, provided that, when R3 is a hydrogen atom, R4 represents a group other than methyl, and the use thereof as a medicine.