The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Nov. 15, 2005

Filed:

Apr. 17, 2003
Applicants:

Jeffrey W. Corbett, Portage, MI (US);

Michael Dalton Ennis, Mattawan, MI (US);

Kristine E. Frank, Portage, MI (US);

Jian-min Fu, Kalamazoo, MI (US);

Robert Louis Hoffman, Kalamazoo, MI (US);

Patrick R. Verhoest, Augusta, MI (US);

Inventors:

Jeffrey W. Corbett, Portage, MI (US);

Michael Dalton Ennis, Mattawan, MI (US);

Kristine E. Frank, Portage, MI (US);

Jian-Min Fu, Kalamazoo, MI (US);

Robert Louis Hoffman, Kalamazoo, MI (US);

Patrick R. Verhoest, Augusta, MI (US);

Assignee:

Pharmacia & Upjohn, Kalamazoo, MI (US);

Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K031/497 ; A61K031/4965 ; C07D401/00 ; C07D403/00 ; C07D405/00 ;
U.S. Cl.
CPC ...
Abstract

The present invention provides substituted pyrazine derivatives of Formula I,that are CRFreceptor antagonists, including human CRFreceptors. This invention also relates to use of compounds of the invention for treating a disorder or condition, the treatment of which can be effected or facilitated by antagonizing a CRF receptor, such as CNS disorders, particularly anxiety-related disorders and mood disorders.


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