The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 15, 2005
Filed:
Apr. 06, 1998
Jose C. Gutierrez-rocca, Miami, FL (US);
Janice L. Cacace, Miami, FL (US);
Sami Selim, Irvine, CA (US);
Robert Testman, Corona, CA (US);
J. Michael Rutledge, Riverdale, NY (US);
Jose C. Gutierrez-Rocca, Miami, FL (US);
Janice L. Cacace, Miami, FL (US);
Sami Selim, Irvine, CA (US);
Robert Testman, Corona, CA (US);
J. Michael Rutledge, Riverdale, NY (US);
Baker Norton Pharmaceuticals, Inc., Miami, FL (US);
Abstract
Pharmaceutical compositions for oral administration to mammalian subjects comprise a taxane or taxane derivative (e.g., paclitaxel or docetaxel) as active ingredient and a vehicle comprising at least 30% by weight of a carrier for the taxane, said carrier having an HLB value of at least about 10. The compositions may also comprise 0–70% of a viscosity-reducing co-solubilizer. The compositions may be incorporated into conventional oral pharmaceutical dosage forms, or can be in the form of a two-part medicament wherein the first part includes the taxane in a solubilizing vehicle and the second part comprises a carrier for the taxane to promote oral absorption. Methods of treatment of taxane-responsive disease conditions employing the novel compositions are also disclosed, whereby the compositions can be administered alone or in association with an oral bioavailability enhancing agent.