The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 15, 2005
Filed:
May. 10, 2002
Thomas P. Zimmerman, Raleigh, NC (US);
Valery Novokhatny, Raleigh, NC (US);
Kyle A. Landskroner, Mill Valley, CA (US);
Gary J. Jesmok, Richmond, CA (US);
Kathryn K. Taylor, Apex, NC (US);
Thomas P. Zimmerman, Raleigh, NC (US);
Valery Novokhatny, Raleigh, NC (US);
Kyle A. Landskroner, Mill Valley, CA (US);
Gary J. Jesmok, Richmond, CA (US);
Kathryn K. Taylor, Apex, NC (US);
Talecris Biotherapeutics, Inc., Research Triangle Park, NC (US);
Abstract
Methods of thrombolysis that allow the use of a fibrinolytic composition comprising reversibly inactivated acidified plasmin and the localized delivery of the plasmin to a vascular thrombotic occlusion are disclosed. Further disclosed is a method for administering a therapeutic dose of a fibrinolytic composition substantially free of plasminogen activator to a human or animal having a vascular thrombotic occlusion. The fibrinolytic composition includes a reversibly inactivated acidified plasmin substantially free of plasminogen activator. Intravascular catheter delivery of the fibrinolytic composition directly into or in the immediate vicinity of the thrombus is disclosed to minimize the systemic degradation of fibrin while retaining the maximum plasmin activity against the thrombus.