The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 15, 2005
Filed:
Jan. 21, 2003
Sukanta Banerjee, North Brunswick, NJ (US);
Cecilia Georgescu, Piscataway, NJ (US);
Eric S. Daniels, Bethlehem, PA (US);
Victoria L. Dimonie, Bethlehem, PA (US);
Michael Seul, Fanwood, NJ (US);
Sukanta Banerjee, North Brunswick, NJ (US);
Cecilia Georgescu, Piscataway, NJ (US);
Eric S. Daniels, Bethlehem, PA (US);
Victoria L. Dimonie, Bethlehem, PA (US);
Michael Seul, Fanwood, NJ (US);
Bioarray Solutions, Ltd., Warren, NJ (US);
Abstract
A dye, such as a fluorescent dye, is incorporated into polymer microparticles using a solvent system composed of a first solvent in which the dye and the microparticle polymer are soluble, a second solvent in which the dye and the microparticle polymer are not or only weakly soluble, and a third solvent in which the dye and the microparticle polymer are not or only weakly soluble. The first and second solvents are immiscible with each other, or at most partially miscible. The third solvent is miscible with the first and second solvents. The formulation provides substantially complete partitioning of the dye to the microparticles. The method may be used to obtain dyed polymer microparticle formed of cross-linked or non-cross-linked polymers. Libraries are provided comprising two or more sets of microparticles of different dye loadings. Fluorescent core-shell microparticles are produced from a mixture of microparticle cores incorporating one or more fluorescent dyes, a polymerization mixture comprising at least one polymerizable shell monomer, at least one free radical polymerization initiator comprising a water-insoluble oxidizing agent, and at least one water-soluble reducing agent.