The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 08, 2005
Filed:
May. 08, 1997
Applicants:
Kathryn Lindsay Ball, Dundee, GB;
David Philip Lane, Fife, GB;
Inventors:
Kathryn Lindsay Ball, Dundee, GB;
David Philip Lane, Fife, GB;
Assignee:
Cyclacel Limited, Scotland, GB;
Primary Examiner:
Int. Cl.
CPC ...
G01N033/53 ; G01N033/569 ; G01N033/566 ;
U.S. Cl.
CPC ...
Abstract
p21interacts with cyclin D1 and Cdk4. Peptide fragments of p21 inhibit the interaction and/or affect Cdk4 activity. The peptides, derivative peptides and non-peptidyl mimetics thereof are useful in affecting activity of Cdk4, such as RB phosphorylation, and cellular proliferation, indicative of therapeutic usefulness in treatment of tumours and other hyperproliferative disorders. Assay and screening methods allow identification of such modulators, especially inhibitors, of Cdk4 activity.