The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 01, 2005
Filed:
Nov. 13, 2003
Kazuo Nishimura, Osaka, JP;
Masakazu Ban, Osaka, JP;
Ken-ichi Fujimura, Osaka, JP;
Naoyuki Kobayashi, Osaka, JP;
Masanori Hori, Osaka, JP;
Takahiro Honda, Osaka, JP;
Eiko Matsumoto, Ashiya, JP;
Kazuo Nishimura, Osaka, JP;
Masakazu Ban, Osaka, JP;
Ken-ichi Fujimura, Osaka, JP;
Naoyuki Kobayashi, Osaka, JP;
Masanori Hori, Osaka, JP;
Takahiro Honda, Osaka, JP;
Eiko Matsumoto, Ashiya, JP;
Santen Pharmaceutical Co., Ltd., Osaka, JP;
Abstract
A compound having 3-oxo-3, 4-dihydro-2H-1, 4-thiazine 4-tetrahydropyrazine as a main skeleton. The compound is a chymase inhibitor and is represented by the following formula [I] and salts thereof:In the formula [I], X is S; Rand Rare H, alkyl, cycloalkyl or aryl; Rand Rare H, alkyl, cycloalkyl, aryl or an aromatic heterocycle; Ris H, alkyl, cycloalkyl, aryl or -A-A-R; Ris H, alkyl, cycloalkyl, hydroxy, alkoxy, aryl, aryloxy or an aromatic heterocycle; Ris H, alkyl, hydroxy, alkoxy, aryl, aryloxy, amino, alkylamino, arylamino, an aromatic heterocycle or a nonaromatic heterocycle; Ais alkylene; Ais carbonyl or sulfonyl; Ais alkylene; Ais carbonyl or oxalyl; and n is 0 or 1.