The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 25, 2005
Filed:
Jul. 18, 2003
Robert E. Maleczka, Jr., DeWitt, MI (US);
Milton R. Smith, Iii, East Lansing, MI (US);
Daniel Holmes, DeWitt, MI (US);
Robert E. Maleczka, Jr., DeWitt, MI (US);
Milton R. Smith, III, East Lansing, MI (US);
Daniel Holmes, DeWitt, MI (US);
Board of Trustees of Michigan State University, East Lansing, MI (US);
Abstract
A process is described for synthesizing aminoarylboronic esters of the general formulawherein R, R, and Rare each an alkyl, aryl, vinyl, alkoxy, carboxylic esters, amides, or halogen; Ar is any variety of phenyl, naphthyl, anthracyl, heteroaryl; and Ris alkyl, hydrogen, or aryl. The aminoarylboronic esters are produced via the metal-catalyzed coupling of arylboronic esters of the general formulawherein R and Rare any non-interfering group and X is chloro, bromo, iodo, triflates, or nonaflates to amines (primary and secondary). In particular, a process is described for the synthesis of the aminoarylboronic esters via a step-wise or tandem process in which one catalytic event is a metal-catalyzed borylation and the other catalytic event is a metal-catalyzed amination.