The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 25, 2005
Filed:
Apr. 29, 2003
Marudai Balasubramanian, Indianapolis, IN (US);
Joel R. Calvin, Carmel, IN (US);
Eric F. V. Scriven, Greenwood, IN (US);
Charles R. Hopper, Plainfield, IN (US);
Ramiah Murugan, Indianapolis, IN (US);
L. Mark Huckstep, Avon, IN (US);
Marudai Balasubramanian, Indianapolis, IN (US);
Joel R. Calvin, Carmel, IN (US);
Eric F. V. Scriven, Greenwood, IN (US);
Charles R. Hopper, Plainfield, IN (US);
Ramiah Murugan, Indianapolis, IN (US);
L. Mark Huckstep, Avon, IN (US);
Reilly Industries, Inc., Indianapolis, IN (US);
Abstract
Processes for preparing a 4-(secondary or tertiary)aminopyridine are provided. The processes comprise reacting a 4-substituted pyridine base having a leaving group as the 4-substituent, with an activating agent so as to form a corresponding 1,4-substituted pyridine; reacting the 1,4-substituted pyridine with a primary or secondary amine to substitute an amino group at the 4-position, and thereby form a corresponding 1-substituted-4-(secondary or tertiary) aminopyridine, wherein the reacting is conducted in a substitution reaction medium essentially free from strong base; and treating the 1-substituted-4-aminopyridine compound to remove the 1-substituent and thereby form a product medium including the 4-(secondary or tertiary) amino-pyridine.