The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 25, 2005
Filed:
Jul. 03, 2001
Baldomero M. Olivera, Salt Lake City, UT (US);
J. Michael Mcintosh, Salt Lake City, UT (US);
Doju Yoshikami, Salt Lake City, UT (US);
G. Edward Cartier, Salt Lake City, UT (US);
Siqin Luo, Salt Lake City, UT (US);
Baldomero M. Olivera, Salt Lake City, UT (US);
J. Michael McIntosh, Salt Lake City, UT (US);
Doju Yoshikami, Salt Lake City, UT (US);
G. Edward Cartier, Salt Lake City, UT (US);
Siqin Luo, Salt Lake City, UT (US);
University of Utah Research Fnd., Salt Lake City, UT (US);
Cognetix, Inc., Salt Lake City, UT (US);
Abstract
The present invention relates to the use of α-conotoxin peptides having the general formula Xaa-Xaa-Cys-Cys-Xaa-Xaa-Pro-Xaa-Cys-Xaa-Xaa-Xaa-Xaa-Xaa-Xaa-Xaa-Cys (SEQ ID NO:1) for treating disorders regulated at neuronal nicotinic acetylcholine receptors. Such disorders include, but are not limited to, cardiovascular disorders, gastric motility disorders, urinary incontinence, nicotine addiction, mood disorders (such as bipolar disorder, unipolar depression, dysthymia and seasonal effective disorder) and small cell lung carcinoma, as well as the localization of small cell lung carcinoma. In this formula, Xaais des-Xaa, Tyr, mono-iodo-Tyr or di-iodo-Tyr, Xaais any amino acid, Xaais any amino acid, Xaais any amino acid, Xaais any amino acid; Xaais any amino acid, Xaais any amino acid, Xaais any amino acid, Xaais des-Xaaor any amino acid, Xaais des-Xaaor any amino acid, Xaais des-Xaaor any amino acid and Xaais des-Xaaor any amino acid. Disulfide linkages exist between the first and third cysteines and the second and fourth cysteines. Pro may be replaced with hydroxy-Pro. The C-terminus may contain a hydroxyl or an amide group, preferably an amide group.