The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 18, 2005
Filed:
Oct. 29, 1999
Nnochiri N. Ekwuribe, Cary, NC (US);
Balasingam Rhadakrishnan, Chapel Hill, NC (US);
Christopher H. Price, Chapel Hill, NC (US);
Wes Anderson Jr., Raleigh, NC (US);
Aslam M. Ansari, Durham, NC (US);
Nnochiri N. Ekwuribe, Cary, NC (US);
Balasingam Rhadakrishnan, Chapel Hill, NC (US);
Christopher H. Price, Chapel Hill, NC (US);
Wes Anderson Jr., Raleigh, NC (US);
Aslam M. Ansari, Durham, NC (US);
Nobex Corporation, Durham, NC (US);
Abstract
The present invention relates to amphiphilic drug-oligomer conjugates capable of traversing the blood-brain barrier ('BBB') and to methods of making and using such conjugates. An amphiphilic drug-oligomer conjugates comprise a therapeutic compound conjugated to an oligomer, wherein the oligomer comprises a lipophilic moiety coupled to a hydrophilic moiety. The conjugates of the invention further comprise therapeutic agents such as proteins, peptides, nucleosides, nucleotides, antiviral agents, antineoplastic agents, antibiotics, etc., and prodrugs, precursors, derivatives and intermediates thereof, chemically coupled to amphiphilic oligomers.