The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 18, 2005
Filed:
Nov. 14, 2001
Jiradej Manosroi, Chiang Mai, TH;
Aranya Manosroi, Chiang Mai, TH;
Chatchai Tayapiwatana, BKK, TH;
Friedrich Goetz, Tuebingen, DE;
Rolf-guenther Werner, Biberach, DE;
Jiradej Manosroi, Chiang Mai, TH;
Aranya Manosroi, Chiang Mai, TH;
Chatchai Tayapiwatana, BKK, TH;
Friedrich Goetz, Tuebingen, DE;
Rolf-Guenther Werner, Biberach, DE;
Abstract
The invention belongs to the field of thrombolysis and of tissue plasminogen activator (tPA) derivative production in prokaryotic cells. The invention relates to methods for the production of a recombinant DNA-derived tPA, a variant therof or a (Kringle 2 Serine) K2S molecule or a variant therof in prokaryotic cells, wherein the tPA or K2S or variant is secreted extracellularly as an active and correctly folded protein, and the prokaryotic cell contains and expresses a vector comprising the DNA coding for the tPA or K2S or variant operably linked to the DNA coding for the signal peptide OmpA. The invention further relates to specific K2S derivatives obtainable by the method. The invention further relates to the DNA molecules and the use of the DNA molecules in the methods.