The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 11, 2005
Filed:
Nov. 05, 1999
Joseph M. Kinkade, Jr., Decatur, GA (US);
Raymond Shapira, Atlanta, GA (US);
Peter E. Jensen, Atlanta, GA (US);
Ngoc-anh Le, Decatur, GA (US);
Jan Pohl, Tucker, GA (US);
W. Virgil Brown, Atlanta, GA (US);
Joseph M. Kinkade, Jr., Decatur, GA (US);
Raymond Shapira, Atlanta, GA (US);
Peter E. Jensen, Atlanta, GA (US);
Ngoc-Anh Le, Decatur, GA (US);
Jan Pohl, Tucker, GA (US);
W. Virgil Brown, Atlanta, GA (US);
Emory University, Atlanta, GA (US);
Abstract
This invention related generally to methods of detecting and quantifying biomarkers of oxidative stress in proteins. The biomarker may be any amino acid that has undergone oxidation (or other modification, e.g. chloro-tyrosine, dityrosine). Emphasis is given herein on oxidized sulfur- or selenium-containing amino acids (SSAA). The biomarker of oxidative stress in proteins may be detected with an antibody that binds to oxidized amino acids, specifically oxidized sulfur- or selenium-containing amino acids. The antibody may be monoclonal or polyclonal. The presence of biomarker or amount of biomarker present in a sample may be used to aid in assessing the efficacy of environmental, nutritional and therapeutic interventions, among other uses.