The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 04, 2005
Filed:
Nov. 30, 2001
Peter P. Roller, Rockville, MD (US);
Ya-qiu Long, Bethesda, MD (US);
Feng-di T. Lung, Taichung, TW;
C. Richter King, Washington, DC (US);
Dajun Yang, Gaithersburg, MD (US);
Peter P. Roller, Rockville, MD (US);
Ya-Qiu Long, Bethesda, MD (US);
Feng-Di T. Lung, Taichung, TW;
C. Richter King, Washington, DC (US);
Dajun Yang, Gaithersburg, MD (US);
The United States of America as represented by the Department of Health and Human Services, Washington, DC (US);
Georgetown University, Washington, DC (US);
Abstract
A compound of formula:in which L is sulfur, sulfoxide, oxygen or methylene, and a compound of formula:in which (i) aais Adi and aais Glu or (ii) each of aaand aais Adi, L is sulfur, sulfoxide, oxygen or methylene, which compounds (and their conjugates) bind to an SH2 domain in a protein comprising an SH2 domain, are non-phosphorylated, are redox-stable in vivo, are characterized by an ICin vivo of less than about 4.0 μM with respect to the SH2 domain in Grb2, and, upon binding to the SH2 domain of Grb2, have a turn conformation. A conjugate comprising a compound as described above and a carrier agent, a composition comprising (i) a compound or a conjugate as described above and (ii) a carrier, a method of inhibiting binding of an SH2 domain in a protein comprising an SH2 domain to a target protein in an animal, wherein the SH2 domain is contacted with a target protein-binding inhibiting effective amount of a compound or a conjugate as described above, and a method of synthesizing such conjugates.