The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 27, 2005
Filed:
Dec. 23, 1998
Stephen H. Friend, Philadelphia, PA (US);
Roland Stoughton, San Diego, CA (US);
Yudong He, Kirkland, WA (US);
Stephen H. Friend, Philadelphia, PA (US);
Roland Stoughton, San Diego, CA (US);
Yudong He, Kirkland, WA (US);
Rosetta Inpharmatics LLC, Seattle, WA (US);
Abstract
The invention provides methods for removing unwanted response components (i.e., 'artifacts') from a measured biological profile comprising measurements of a plurality of cellular constituents of a cell or organism in response to a perturbation. The methods involve subtracting from the measured biological profile one or more artifact patterns, each of which comprises measurements of changes in cellular constituents as a result of deviation of one or more experimental variables, such as cell culture density and temperature, hybridization temperature, as well as concentrations of total RNA and/or hybridization reagents, from desired values.