The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 27, 2005
Filed:
Jun. 05, 2003
Eu-gene OH, Taejon, KR;
Sung-bo Ko, Taejon, KR;
Won-yeob Kim, Taejon, KR;
Kyung-hwa Kim, Taejon, KR;
Dennis W. Choi, St. Louis, MO (US);
Laura L. Dugan, St. Louis, MO (US);
Tae-cheon Kang, Chuncheon, KR;
Jae-young Koh, Seoul, KR;
Kyung-mi Kim, Sungnam, KR;
In-jae Shin, Koyang, KR;
Eu-Gene Oh, Taejon, KR;
Sung-Bo Ko, Taejon, KR;
Won-Yeob Kim, Taejon, KR;
Kyung-Hwa Kim, Taejon, KR;
Dennis W. Choi, St. Louis, MO (US);
Laura L. Dugan, St. Louis, MO (US);
Tae-Cheon Kang, Chuncheon, KR;
Jae-Young Koh, Seoul, KR;
Kyung-Mi Kim, Sungnam, KR;
In-Jae Shin, Koyang, KR;
Sam-Sung Electronics Co., Ltd., Kyunggi-do, KR;
Abstract
The present invention provides novel N-alkyl-N-phenylhydroxylamine derivatives containing metal chelating groups, a process for preparing the same, the use of the novel compounds as therapeutics for treating and/or preventing various medical dysfunctions and diseases arising from reactive oxygen species (ROS) and/or excess Zn ions, in particular stroke, Parkinson's disease and Alzheimer's disease. The compounds of the invention possess similar or superior LPO inhibition activity to the reference compounds of Trolox and Ebselen. While showing lower toxicity, they also effectively inhibit the cerebral neuronal cell death caused by ROS and/or zinc ion, and show neuroprotective effects against ischemic neuronal degeneration.