The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 27, 2005
Filed:
Dec. 20, 2001
Applicants:
George R. Pettit, Paradise Valley, AZ (US);
Noeleen Melody, Mesa, AZ (US);
Inventors:
George R. Pettit, Paradise Valley, AZ (US);
Noeleen Melody, Mesa, AZ (US);
Assignee:
Arizona Board of Regents, Tempe, AZ (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D491/056 ;
U.S. Cl.
CPC ...
Abstract
(+)-Narciclasine (2), available in quantity from certainspecies or by total synthesis, is employed in for a ten step synthetic conversion (3.6% overall yield) to natural (+)-pancratistatin (1a). The key procedures involve the epoxidation of natural (+)-narciclasine (2) to an epoxide (6), reduction of the epoxide (6) to diol (8), formation of cyclic sulfate (12) and its ring opening with cesium benzoate followed by saponification of the benzoate to afford (+)-pancratistatin (1a).