Remedial agent for anxiety neurosis or depression and piperazine derivative

Abstract

There are provided a therapeutic preparation for anxiety neurosis or depression which comprises a MCreceptor antagonist as an effective ingredient; and a piperazine derivative represented by Formula [1]:[wherein Aris a phenyl group, a substituted phenyl group, a naphthyl group or a substituted naphthyl group; Aris a naphthyl group, a substituted naphthyl group, a quinolyl group, a group represented by the formula:(wherein Ris a hydrogen atom or a halogen atom; and X—Y is CH—NH, CH—O, CH—S or N—O) or a group represented by the formula:(wherein Ris a hydrogen atom, a hydroxyl group or a Calkoxy group); Ris a hydrogen atom, a Calkyl group, a Ccycloalkyl group, a Calkenyl group, a phenyl group, a 1-cyanoethyl group, a pyrimidin-2-yl group or an amidyl group; Rand Rare the same or different, and are each a hydrogen atom or a Calkyl group; A-B is N—CH, CH—CH, C(OH)—CHor C═CH; Tis a single bond, —N(R)— (wherein Ris a hydrogen atom or a Calkyl group), —O—, —CH═CH— or —C(═O)—; n is an integer of from 1 to 10 and when Tis a single bond, —CH═CH— or —C(═O)—, n is an integer of from 2 to 10 when Tis —N(R)— or —O—], or a pharmaceutically acceptable salt thereof.