The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 27, 2005
Filed:
Sep. 13, 2002
Stanislaw Pikul, Germantown, MD (US);
Norman Eugene Ohler, New Market, MD (US);
Neil Gregory Almstead, Holmdel, NJ (US);
Steven Karl Laughlin, Independence, KY (US);
Michael George Natchus, Alpharetta, GA (US);
Biswanath DE, Cincinnati, OH (US);
Paul Mitchell Hershberger, Maineville, OH (US);
Stanislaw Pikul, Germantown, MD (US);
Norman Eugene Ohler, New Market, MD (US);
Neil Gregory Almstead, Holmdel, NJ (US);
Steven Karl Laughlin, Independence, KY (US);
Michael George Natchus, Alpharetta, GA (US);
Biswanath De, Cincinnati, OH (US);
Paul Mitchell Hershberger, Maineville, OH (US);
The Procter & Gamble Company, Cincinnati, OH (US);
Abstract
Disclosed are compounds which are inhibitors of metalloproteases and which are effective in treating conditions characterized by excess activity of these enzymes. In particular, the compounds have a structure according to the following Formula (I):where R, R, R, n, A, E, X, G, G', M and Z have the meanings described in the specification and the claims, as well as optical isomers, diastereomers and enantiomers of Formula I, and pharmaceutically-acceptable salts, biohydrolyzable amides, esters, and imides thereof. Also described are pharmaceutical compositions comprising these compounds, and methods of treating metalloprotease-related maladies using the compounds or the pharmaceutical compositions.