The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 27, 2005
Filed:
Mar. 28, 2002
Randy S. Bethiel, Arlington, MA (US);
John Cochran, North Andover, CA (US);
Young-choon Moon, Lexington, MA (US);
Suganthini Nanthakumar, Newton, MA (US);
Randy S. Bethiel, Arlington, MA (US);
John Cochran, North Andover, CA (US);
Young-Choon Moon, Lexington, MA (US);
Suganthini Nanthakumar, Newton, MA (US);
Vertex Pharmaceuticals Incorporated, Cambridge, MA (US);
Abstract
The present invention provide a compound of formula I or II:or a pharmaceutically acceptable derivative thereof, wherein R, R, R, and Rare as described in the specification. These compounds are inhibitors of protein kinase, particularly inhibitors of JNK, a mammalian protein kinase involved cell proliferation, cell death and response to extracellular stimuli; and Src-family kinases, especially Src and Lck kinases. These compounds are also inhibitors of GSK3 and CDK2 kinases. The invention also relates to methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing those compositions in the treatment and prevention of various disorders.