The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 27, 2005
Filed:
Aug. 18, 1994
David C. Rueger, Hopkinton, MA (US);
Kuber T. Sampath, Medway, MA (US);
John E. Smart, Weston, MA (US);
Hermann Oppermann, Medway, MA (US);
Engin Ozkaynak, Milford, MA (US);
Charles M. Cohen, Weston, MA (US);
Dennis Higgins, Amherst, NY (US);
David C. Rueger, Hopkinton, MA (US);
Kuber T. Sampath, Medway, MA (US);
John E. Smart, Weston, MA (US);
Hermann Oppermann, Medway, MA (US);
Engin Ozkaynak, Milford, MA (US);
Charles M. Cohen, Weston, MA (US);
Dennis Higgins, Amherst, NY (US);
Curis, Inc., Cambridge, MA (US);
The Research Foundation of State University of New York, Amherst, NY (US);
Abstract
Disclosed are methods and compositions for maintaining neural pathways in a mammal including: enhancing survival of neurons at risk of dying; inducing cellular repair of damaged neurons and neural pathways; stimulating neurons to maintain their differentiated phenotype; and promoting dendritic outgrowth, including maintaining dendritic arbors and regenerating dendritic architecture. In one embodiment, the invention provides means for stimulating CAM expression in neurons. The invention also provides means for evaluating the status of nerve tissue, including means for detecting and monitoring neuropathies in a mammal. The methods, devices and compositions include a morphogen or morphogen-stimulating agent provided to the mammal in a therapeutically effective concentration. In another embodiment, the invention provides methods and compositions which include a morphogen or morphogen-stimulating agent, and a nerve trophic factor or nerve trophic factor-stimulating agent at concentrations effective for stimulating dendrite outgrowth. The morphogen and the nerve trophic factor can be admixed in combination.