The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 20, 2005
Filed:
Jun. 29, 2004
Arthur J. Elliott, Aiken, SC (US);
David A. Walsh, Birmingham, AL (US);
Philip E. Morris, Birmingham, AL (US);
Arthur J. Elliott, Aiken, SC (US);
David A. Walsh, Birmingham, AL (US);
Philip E. Morris, Birmingham, AL (US);
BioCryst Pharmaceuticals, Inc., Birmingham, AL (US);
Abstract
Derivatives of 9-deazaguanine of the formula I:are prepared by reacting an aldehyde or ketone of the formula II:with a dialkylaminomalonate to produce an enamine. The enamine is then reacted with a base to produce a pyrrole represented by the formula:The pyrrole is reacted with a compound represented by the formula ROC(O)N═C(Z)NHC(O)ORor a derivative of carbamimidoic acid to provide a protected guanidine compound. The guanidine compound is converted to the desired deazaguanine by reaction with 1) trifluoracetic acid or 2) C-Calkoxide or alkali metal or alkaline earth metal hydroxide followed by neutralization with an acid.