The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 13, 2005
Filed:
Sep. 15, 2003
Mitchell P. Fink, Pittsburgh, PA (US);
Luis Ulloa, Jackson Heights, NY (US);
Kevin J. Tracey, Old Greenwich, CT (US);
Russell L. Delude, Pittsburgh, PA (US);
Mitchell P. Fink, Pittsburgh, PA (US);
Luis Ulloa, Jackson Heights, NY (US);
Kevin J. Tracey, Old Greenwich, CT (US);
Russell L. Delude, Pittsburgh, PA (US);
University of Pittsburgh-of the Commonwealth System of Higher Education, Pittsburgh, PA (US);
North Shore-Long Island Jewish Research Institute, Great Neck, NY (US);
Abstract
This invention is directed to a method of using a therapeutic composition comprising a compound of an alpha-ketoalkanoic acid (pyruvate) and/or its derivatives for the treatment of cytokine-mediated inflammatory conditions. The compound is an alpha-ketoalkanoic acid, a physiologically acceptable salt of an alpha-ketoalkanoic acid, an ester of an alpha-ketoalkanoic acid, or an amide of an alpha-ketoalkanoic acid. A component for inducing and stabilizing the enol resonance form of the ester at physiological pH values is also disclosed. The cytokine-mediated inflammatory conditions are mediated by, for example, an 'early' (Tumor Necrosis Factor (TNF), interleukin-1β (IL-1β)) or 'late' (high mobility group B-1 (HMGB-1)) mediator of inflammation. Exemplary cytokine-mediated inflammatory conditions include, but are not limited to, local and systemic inflammation, inflammatory bowel disease (Crohn's disease and ulcerative colitis), rheumatoid arthritis, asthma (including status asthmaticus), sepsis or septic shock, also including inflammatory skin conditions, for example, psoriasis and eczema.