The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 13, 2005
Filed:
Apr. 16, 2001
William Alexander Denny, Auckland, NZ;
Richard H. Hutchings, Ann Arbor, MI (US);
Douglas S. Johnson, Dexter, MI (US);
James Stanley Kaltenbronn, Ann Arbor, MI (US);
Ho Huat Lee, Auckland, NZ;
Daniele Marie Leonard, Ann Arbor, MI (US);
Jared Bruce John Milbank, Dexter, MI (US);
Joseph Thomas Repine, Ann Arbor, MI (US);
Gordon William Rewcastle, Auckland, NZ;
Andrew David White, Pinckney, MI (US);
William Alexander Denny, Auckland, NZ;
Richard H. Hutchings, Ann Arbor, MI (US);
Douglas S. Johnson, Dexter, MI (US);
James Stanley Kaltenbronn, Ann Arbor, MI (US);
Ho Huat Lee, Auckland, NZ;
Daniele Marie Leonard, Ann Arbor, MI (US);
Jared Bruce John Milbank, Dexter, MI (US);
Joseph Thomas Repine, Ann Arbor, MI (US);
Gordon William Rewcastle, Auckland, NZ;
Andrew David White, Pinckney, MI (US);
Pfizer Inc, New York, NY (US);
Abstract
The present invention provides novel 5-substituted tetralones of Formulas I, II, III, and IV and pharmaceutically acceptable salts, esters, amides, and prodrugs thereof, which are useful for treating and preventing uncontrolled or abnormal proliferation of tissues, such as cancer, atherosclerosis, restenosis, and psoriasis. Specifically, the present invention relates to compounds that inhibit the farnesyl transferase enzyme